Rome was a major world centre of the Renaissance, second only to Florence, and was profoundly affected by the movement. The most impressive masterpiece of Renaissance architecture in Rome is the Piazza del Campidoglio by Michelangelo, along with the Palazzo Senatorio, seat of the city government. During this period, the great aristocratic families of Rome used to build opulent dwellings as the Palazzo del Quirinale (now seat of the President of the Italian Republic), the Palazzo Venezia, the Palazzo Farnese, the Palazzo Barberini, the Palazzo Chigi (now seat of the Italian Prime Minister), the Palazzo Spada, the Palazzo della Cancelleria, and the Villa Farnesina.

Rome is also famous for her huge and majestic squares (often adorned with obelisks), many of which were built in the 17th century. The principal squares are Piazza Navona, Piazza di Spagna, Campo de’ Fiori, Piazza Venezia, Piazza Farnese and Piazza della Minerva. One of the most emblematic examples of Baroque art is the Fontana di Trevi by Nicola Salvi. Other notable 17th-century baroque palaces are the Palazzo Madama, now the seat of the Italian Senate and the Palazzo Montecitorio, now the seat of the Chamber of Deputies of Italy.